What is CBC ? - Green Brothers

What is CBC ?

2 February 2021

CBC Presentation

Like all cannabinoids, it is believed the CBC interacts with the endocannabinoid system, which works to maintain balance at a cellular level by making cannabinoid molecules when needed. This cellular balance is essential for physical and psychological health. CBC differs from the majority of cannabinoids because of its low affinity with CB receptors. Instead, CBC binds to TRPV receptors involved in detecting temperature change and other sensations at the cellular level.

CBC stands for Cannabichromenenot to be confused with the more popular cannabinoid Cannabidiol which stands for CBD.

What is it?

– CBC seems non-psychotropic.

– It is one of the three major cannabinoids synthesized from CBGA.

– It plays a crucial role in optimising the entourage effect.

– It shows a low affinity for the CB1 and CB2 receptors.

– It activates the TRPV1 and TRPA1 receptors located in the cell membrane.

– It could support the treatment of pain and inflammation.

How it works?

CBC has many therapeutic properties due to its activity on the endocannabinoid system and because it shows a particularly strong affinity with TRPV1 & TRPV2. These 2 receptors are well-known to work as pain receptors.


CBC’s effect on other cannabinoids was exhibited in a 2011 study published in Drug and Alcohol Dependence. Not only did the cannabinoid appear to mediate the psychotropic effects of THC, but dose-dependant administration of both cannabinoids in-vitro “led to enhanced tetrad and anti-inflammatory actions”. The most significant point of difference with CBC was that its anti-inflammatory effects weren’t a result of binding with CB1 or CB2 receptors. 


A 2010 study by the University of Mississippi evaluated the effects of THC, CBD, CBC, CBG, and CBN on an animal model of depression. Using a variety of doses, the researchers concluded that “cannabinoids exert antidepressant-like actions”, although for CBC, the effects were dose-dependent. This action varies according to the dose used, with CBC being the most promising (the dose needed is less than 20 mg/kg, when 200 mg/kg is needed for CBD to act).


A 2013 in vitro study using mouse cells showed that CBC, among other cannabinoids, had the most profound positive effects on the viability of neural stem progenitor cells. These cells are crucial for brain plasticity under normal physiological conditions, as well as following brain injury. These cells Astrocytes play an important role in brain homeostasis, however, they are also associated with Alzheimer’s disease pathology. CBC may help to prevent neural stem progenitor cells from differentiating into astrocytes, thereby achieving a pro-neurogenic effect.


CBC appears to exert an anti-inflammatory effect. Inflammation is the body’s response to various pathogens, injuries, and medical conditions, and is associated with many diseases. Once again, research here is very preliminary, but CBC has been shown to reduce inflammation in some models. A 2011 study showed that CBC elicited a dose-dependent anti-inflammatory response in an animal model through a non-cannabinoid receptor mechanism of action.


CBC has been shown to reduce the activity of proteins involved in pain mechanisms. A 2011 paper tested the effects of this cannabinoid on pain on anaesthetised rats.

Researchers found that CBC had pain-reducing effects on the so-called tail flick-test. CBC was found to significantly increase the quantities of endocannabinoids within the periaqueductal gray, the primary control centre for descending pain modulation. The researchers concluded that CBC may be a useful future therapeutic agent with multiple mechanisms of action.


Although CBD is favoured for its reduction of inflammation and cell proliferation associated with acne, a 2016 study highlighted that CBC might have a similar effect. The cannabinoid “significantly reduced arachidonic acid (AA)-induced ‘acne-like’ lipogenesis”. Results went on to suggest that CBC “show promise to become highly efficient, novel anti-acne agents”. CBC is also a TRPV2 agonist, which is a high-threshold thermosensor and thus offers a treatment for burns. All these actions help to reduce the complications linked to psoriasis, eczema and rosacea, as well as relieving burns. 

How to sell it? 

One of the many nice things about CBC isolate is that it’s easy to use. Because it’s a powder, CBC isolate can be used in a wide variety of ways. Here’s a list of strategies to help you put your CBC isolate to work.

Make tincture

Add a small amount of CBC isolate to coconut or hemp oil, and sell it on tincture bottle.

Create cream 

CBC isolate can be whipped into body or face cream. Rubbing the cream into the skin maximizes CBC’s anti-inflammatory properties.

Cook it  

CBC isolate powder can be added to anything you can eat. Mix it into brownies, cookies, pies, and other baked goods. Dissolve a bit in oil or salad dressing. Fold it into ice cream or pudding. Add a teaspoon to tea or coffee. The possibilities are endless and are limited only by your imagination and the creativity of your customers..

Infuse it 

Add some CBC powder to honey or agave for an infused dietary supplement. You can do this by using a water bath to gently dissolve the CBC in the honey without burning anything.

Vaporize it 

Mix a small amount of CBC isolate into vape oil product or e-liquid for a CBC e-liquid.

Add it to bath bomb

You can add CBC when making your bath bombs, to help improve skin problems. 

Sell it as powder 

Powder can be used with a dabbing rig for a quick pick-me-up and almost instant medical relief. Or can be smoked by sprinkle a pinch of CBC isolate in a joint. 

If you need a helping hand making an informed decision about Green Brothers products, you can also send a message to your usual representative via whatsapp or drop us an email — our support team will be happy to help you.

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